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Title An antimalarial cembranolide from Tanzania soft corals, Lobophytum crassum (von Marenzeller (1886) and L. rotundum (Tixier-Durivault (1957) | ||
Full text
http://hdl.handle.net/1834/1139 | ||
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Date 2005 | ||
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Author(s) Said, S.A. | ||
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Abstract Bioscreening guided fractionation of the extracts of soft corals Lobophytum crassum and L. rotundum using brine shrimp larvae cytotoxicity assay led to the isolation of a cembranolide diterpene (E,E,E)-6,10,14-trimethyl-3-methylene- 3a,4,7,8,11,12,15,15aoctahydrocylotetradeca [b]furan-2(3H)-one (1). This diterpene, identified as cembranolide compound 1, was found to be active against the multidrug-resistant and chloroquine-sensitive strains of Plasmodium falciparum malaria parasite in vitro. It also possessed cytotoxic properties. | ||
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Subject(s) Lobophytum crassum; L. rotundum; Plasmodium falciparum; antimalarial; soft corals; cytotoxic; cembranolide; PARASITES | ||
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Language en | ||
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Publisher WIOMSA | ||
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Relation http://www.wiomsa.org | ||
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Type of publication Article | ||
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Format 58999 bytes; application/pdf | ||
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Identifier Western Indian Ocean Journal of Marine Science, 4 (1), p. 95-98; 0856-860X | ||
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Repository Africa - Ocean Data and Information Network of Africa (OdinAfrica) 
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| Added to C-A: 2008-12-22;01:49:25 |
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