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Title Molecular characterization and epidemiology of the highly pathogenic avian influenza H5N1 in Nigeria
Full text http://hdl.handle.net/2263/9762
Date 2009
Author(s) Fasina, F.O.; Bisschop, S.P.R.; Joannis, Tony M.; Lombin, L.H.; Abolnik, C.
Abstract Avian influenza caused infection and spread throughout Nigeria in 2006. Carcass samples (lung,liver, spleen, heart, trachea and intestine) from the different regions of Nigeria were processed for virus isolation. Infective allantoic fluids were tested for avian influenza viruses (AIV) and Newcastle disease virus using monospecific antisera. Thirty-five isolates were generated and characterized molecularly using the haemagglutinin gene. The molecular analysis indicated that different sublineages of the highly pathogenic avian influenza (HPAI) H5N1 viruses spread throughout Nigeria. We compared the Nigerian isolates with others from Africa and results indicated close similarities between isolates from West Africa and Sudan. Some of the analysed viruses showed genetic drift, and the implications of these for future epidemiology and ecology of avian influenza in Africa require further evaluation. The spread of primary outbreaks was strongly linked to trade (legal and illegal), live bird markets, inappropriate disposal, and poorly implemented control measures. No strong correlation existed between wild birds and HPAI H5N1 in Nigeria. - ARC-Onderstepoort Veterinary Institute, South Africa; The Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria; The Helena Jooste Bursary and National Veterinary Research Institute, Nigeria.
Subject(s) Avian influenza H5N1
Language en
Publisher Cambridge University Press
Relation Adobe Acrobat Reader
Type of publication Article
Rights Cambridge University Press
Identifier Fasina, FO, Bisschop, SPR, Joannis, TM, Lombin, LH & Abolnik, C 2009, 'Molecular characterization and epidemiology of the highly pathogenic avian influenza H5N1 in Nigeria', Epidemiology and Infection, vol. 137, no. 4, pp. 456-463.[http://www.journals.cambridge.org/action/displayJournal?jid=HYG]; 0950-2688; 10.1017/S0950268808000988
Repository Pretoria - University of Pretoria, UPSpace
Added to C-A: 2009-06-22;10:15:39