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Title
Monkeypox: from a neglected tropical disease to a public health threat |
Full text
http://hdl.handle.net/10451/54748 |
Date
2022 |
Author(s)
Antunes, Francisco; Cordeiro, Rita; Virgolino, Ana |
Abstract
Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). - Since the first case of human monkeypox was diagnosed in 1970, the disease remained endemic in several countries in West and Central Africa. In 1996, there was a sudden increase in cases in the Democratic Republic of Congo (DRC), and since 2017 an ongoing outbreak in Nigeria took place, probably related to the population growth, human invasion of MPXV animal habitat reservoirs, and the waning of the cross-protection offered from smallpox immunization, later ending in 1980. Since May 2022, an unprecedented outbreak of human monkeypox has rapidly spread around the world, outside endemic regions of Africa, through new modes of transmission, showing differences in clinical features compared with previous reports. The 2022 MPXV strain belongs to the clade of West Africa but diverges from the original strain, making the virus more transmissible. The authors review the main milestones in more than 50 years of history of human monkeypox, from a rare viral zoonotic infection to a public health emergency. - The writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant numbers UIDB/04295/2020 and UIDP/04295/2020. - info:eu-repo/semantics/publishedVersion |
Subject(s)
Zoonosis; Monkeypox virus; Emerging infectious diseases; West and Central Africa; 2022 outbreak |
Language
eng |
Publisher
MDPI |
Relation
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04295%2F2020/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04295%2F2020/PT; https://www.mdpi.com/journal/idr |
Type of publication
article |
Rights
openAccess; http://creativecommons.org/licenses/by/4.0/ |
Identifier
Antunes, F.; Cordeiro, R.; Virgolino, A. Monkeypox: From A Neglected Tropical Disease to a Public Health Threat. Infect. Dis. Rep. 2022, 14, 772-783; 2036-7430; 10.3390/idr14050079; 2036-7449 |
Repository
Lissabon - University of Lissabon
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Added to C-A: 2022-10-17;08:55:03 |
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